The DeepCool GENOME III Full-Tower Case is designed for enthusiasts and professionals who demand maximum expansion potential, superior cooling options, and a stylish look for their high-performance PC builds. This case aims to balance aesthetics, functionality, and flexibility, making it suitable for gaming setups, workstations, and custom water-cooling systems.
Spacious Interior and Expandability:
One of the standout features of the GENOME III is its spacious full-tower chassis, which provides extensive room for large components. It easily accommodates long graphics cards, tall CPU coolers, and multiple storage drives without compromising airflow or cable management. The case supports motherboard sizes up to E-ATX and beyond, giving users the flexibility to build with high-end and workstation-class components. This large interior also simplifies installation and maintenance, as there is ample space to maneuver during assembly.
Advanced Cooling Support:
Thermal management is a core focus of this case. The GENOME III supports a variety of fan mounting locations, including front, top, rear, and bottom positions, allowing users to configure optimal airflow paths. It is compatible with multiple radiator sizes, including 360mm radiators on the front and top, which is ideal for custom or all-in-one liquid cooling setups. The case’s ventilation design, combined with optional dust filters, helps maintain clean and efficient airflow to keep components cool even during intense workloads.
Premium Aesthetics with Tempered Glass:
The case features tempered glass panels on the front and side, providing a crystal-clear view of the internal components. This is perfect for showcasing RGB lighting and custom builds. The tempered glass is both durable and visually striking, elevating the overall look of any setup. The sleek design, combined with clean lines and a minimalist exterior, ensures the case fits well in modern gaming rooms or professional workspaces.
Cable Management and Convenience Features:
DeepCool has incorporated thoughtful cable management options, including ample routing holes, Velcro straps, and tie points, enabling users to create clean and organized builds. Good cable management not only improves aesthetics but also enhances airflow and cooling efficiency. The case also includes tool-free drive bays and removable panels, making upgrades and maintenance easier and faster.
Storage Flexibility:
The GENOME III supports multiple storage configurations, offering several dedicated 3.5” and 2.5” drive bays. This allows users to install a combination of traditional HDDs and fast SSDs, catering to both large capacity and high-speed storage needs. The drive cages are removable and modular, providing further customization options.
Build Quality and Materials:
Constructed from sturdy steel and tempered glass, the GENOME III delivers robust durability. Its build quality ensures it can handle heavy components and frequent use without issues, providing a solid foundation for demanding builds.
At the heart of the GENOME III lies a pre-installed 420mm all-in-one (AIO) liquid cooling system, powered by DeepCool’s 6th-generation pump and paired with three high-performance FT14 fans. This setup ensures exceptional thermal efficiency and robust airflow, optimized for even the most demanding components. The innovative short-tube design simplifies coolant routing, while a front-mounted, transparent coolant reservoir incorporates Anti-Leak technology for reliable pressure regulation. A vibrant RGB light column, fully compatible with motherboard synchronization, enhances the case’s striking visual appeal, complementing the reservoir’s futuristic design.


Beyond its pre-installed AIO, the GENOME III offers extensive customization for cooling setups. The case supports dual 420mm radiators or up to ten 120mm/140mm fans, providing builders with the flexibility to prioritize silent operation or maximum cooling performance. This makes the GENOME III an ideal choice for enthusiasts crafting high-performance systems tailored to their unique needs.

Engineered to house today’s most powerful components, the DeepCool GENOME III supports E-ATX and SSI-ECB motherboards, GPUs up to 480mm in length, and tower air coolers up to 195mm tall. With nine PCIe expansion slots and multiple drive bays, it accommodates complex multi-device configurations. The case also features 31.5mm of cable management clearance and support for PSUs up to 220mm, ensuring clean, organized builds with ease.

Pros and Cons of DeepCool GENOME III Full-Tower Case
Pros:
- Spacious Interior: The full-tower design provides ample space for high-end components, including large GPUs, multiple storage drives, and advanced cooling solutions.
- Excellent Cooling Support: Supports multiple fan and radiator configurations, including large 360mm radiators, enhancing airflow and liquid cooling options.
- Modular Design: Features a modular and customizable interior layout, allowing for easy installation and upgrades.
- Tempered Glass Panels: Equipped with tempered glass side and front panels for a premium look and the ability to showcase internal components.
- Good Cable Management: Includes comprehensive cable routing options and plenty of tie points to keep the build neat and tidy.
- Durable Build: Made with solid materials, ensuring longevity and stability.
- Multiple Drive Bays: Supports a variety of storage options, including several 3.5″ and 2.5″ drive bays.
Cons:
- Large Size: Its full-tower dimensions can be too large for smaller rooms or desks and may be challenging to transport.
- Price: Positioned in a higher price bracket compared to some mid-tower cases.
- Weight: The case is relatively heavy, which might be inconvenient for users who frequently move their PC.
- Limited Front I/O: Some users might find the front I/O panel somewhat limited in ports compared to other modern cases.
- No Included Fans (or limited fans): Depending on the bundle, the case may come with few or no pre-installed fans, necessitating additional purchases for optimal airflow.
| Product Dimensions | 590×250×582.9mm(L×W×H) |
| Net Weight | 17Kg |
| Materials | ABS+SPCC+Tempered Glass |
| Motherboard Support | Mini-ITX / Micro-ATX / ATX / E-ATX ATX(Rear Connector)/Micro-ATX(Rear Connector) |
| Front I/O Ports | USB3.0×4、Audio×1、Gen-2 TypeC×1 |
| 3.5″ Drive Bays | 1 |
| 2.5″ Drive Bays | 2 |
| Expansion Slots | 9 Slots |
| Pre-Installed Fans | NA |
| Fan Support | Top:3×120 / 3×140/ 2×180mm Bottom:1×120 / 1×140mm PSU Shroud: 2×120 / 2×140mm Side:3×120 / 3×140mm Rear: 1×120 / 1×140mm |
| Radiator Support | Top: Pre-Install 420mm AIO Side:120/140/240/280/360mm/420mm Bottom:120mm PSU Shroud:120/140/240mm Rear: 120/140mm |
| CPU Cooler Height Limit | 195mm |
| GPU Size Limit | 480mm |
| Power Supply Type | ATX PS2(Maximum length: 180mm) |
| EAN | 6933412774075 |
| P/N | R-GENOME-BKALA3-G-3 |
